What is the mechanism of coming out of neutrophils from blood in extra vascular space while serum failed to leak ?

24 November 2018 1 7K Report

Neutrophils are big in size

The exact mechanism is not completely understood. Several signaling molecules (selectins, integrins etc) and adhesion receptors of both neutrophils and endothelial cells are involved in the process of rolling, adhesion and transmural migration of neutrophils into the site of inflammation. So, it is an active biological mechanism different from the extravasation of plasma.

You can read this nice review: Article Mechanisms of neutrophil transendothelial migration

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