BMP signaling agonist sb4 (HY-124697)
What is the specific mechanism by which this small molecule compound Sb4 activates the BMP/PSMAD signaling pathway?
For example, does it promote ligand-receptor binding or inhibit phosphorylating degradative enzymes?
The literature reports indicate that the mechanism of action involves enhancing the activation of p-SMAD-1/5/9. However, further details on the specific activation mechanisms remain unclear, as we do not conduct biological validation experiments. Additionally, studies have shown that BMPSB4 treatment enhances the induction of autophagic flux and elevates the levels of ATG3, ATG7, and the ATG5–ATG12 complex. (PMID: 39543104; PMID: 39022361) The answer to this question is provided by MedChemExpress Technical Support.
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