What is the maximus molecular radius ( nm scale) of biotherapeutic drug?

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Adam B Shapiro

I don't think there is a maximal radius, from a therapeutic perspective. Perhaps you can clarify what process concerns you.

Praveen Kallamvalliillam Sankaran

Hi Sanat,

If it is protein bio-therapeutics, 6-7 nm is max. The glomerular filtration process cannot filter proteins above this hydrodynamic radius. But, in some cases such as PEGylated bio-therapeutic proteins have around 9 nm. However, this is in cases of one which cleared through receptor/ ligand binding.

kind regards

Praveen

Mohd Qasim

For nanocarrier it is approx 200 nm.