What is the logic behind identifying genes present within 500KB (both side) of a SNP locus ?

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Frederic Lepretre

Hi Premanand A.

GWAS are searching for loci associated with a trait or a disease in a window defined by the protocol. having an associated SNP in a region do not mean that this SNP is the causing one, but just that it's closed to the real affecting SNP. they are often named tag SNP since they represent the loci to be associated with the trait. That's why in such study it's regular to search for genes around and see what's wrong.

all the best

fred

Premanand A.

Hi Frederic Lepretre Thanks for answering. Can you please share some reference papers or materials where I can read more about this concept !

you can see this one:

https://www.nature.com/articles/s43586-021-00056-9