I am studying the migration of nanoparticles in a 72hours chick embryo model. However I am not sure about the diameter of the capillaries of 72 hours chick embryo. I want to start with nanoparticle of size 100 nm. I believe they should be fine moving through the arteries and vein, but I am not sure about the capillaries. Should I go for more smaller size nanoparticle? Is their any reference about the diameters where I can check out, as I tried but I was unable to find one.
Many thanks,
Raza
Take a blood sample and look at the size of the red blood cells - the capillaries must be slightly larger than these to allow passage of the cells. I would guess a capillary diameter around 10 microns. See also:
Article Structural damage of chicken red blood cells exposed to plat...
this is a study on mice
....From the available sizes, the set of channels used in this study were 5 μm high and 8 μm wide, with constrictions of 3 μm wide and 10 μm long. ....
Article Red Blood Cell Passage of Small Capillaries Is Associated wi...
Your nanoparticles are 0.1 micrometer in size. Capillaries of the 72 h chick embryo are about 5 to 8 micrometer wide, so the nanoparticles should easily pass them.
Kind regards, Daniela
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