Dear Phung Duong,

The antibiotics are secondary metabolites with broad spectrum of anti-microbial activity. While the bacteriocins (antimicrobial peptides) are synthesized on ribosomes by translation process as they are polymer of amino acids and have a narrow spectrum of anti-microbial activity mainly against closely related species.

Regards,

Ashwini Kumar Dubey

Bacteriocins are proteinaceous toxins produced by bacteria to inhibit the growth of similar or closely related bacterial strain(s). They are similar to yeast and paramecium killing factors, and are structurally, functionally, and ecologically diverse. Applications of bacteriocins are being tested to assess their application as narrow-spectrum antibiotics.Bacteriocins are of interest in medicine because they are made by non-pathogenic bacteria that normally colonize the human body. An example of this would be genus Lactobacilli. These bacteria inhabit the normal, lower reproductive tract of women. Loss of these harmless bacteria following antibiotic use may allow opportunistic pathogenic bacteria to invade the human body.

as for example,Nisin is a polycyclic antibacterial peptide produced by the bacterium Lactococcus lactis that is used as a food preservative.

Antibiotics or antibacterials are a type of antimicrobial used in the treatment and prevention of bacterial infection. They may either kill or inhibit the growth of bacteria.They are produced in nature by soil bacteria and fungi. 

Antibiotics take advantage of the difference between the structure of the bacterial cell and the host’s  cell.

They either prevent the bacterial cells from multiplying so that the bacterial population remains the same, allowing the host’s defence mechanism to fight the infection or kill the bacteria, for example stopping the mechanism responsible for building their cell walls.

An antibiotic can also be classified according to the range of pathogens against which it is effective. Penicillin G will destroy only a few species of bacteria and is known as a narrow spectrum antibiotic. Tetracycline is effective against a wide range of organisms and is known as a broad spectrum antibiotic.

acteriocine , they are typically considered to be narrow spectrum antibiotics. Antibiotics, inhibits the growth of or destroys microorganisms.

Bacteriocins are antibacterial proteins produced by bacteria that kill or inhibit the growth of other bacteria. Many lactic acid bacteria LAB produce a high diversity of different bacteriocins. Though these bacteriocins are produced by LAB Ž found in numerous fermented and non-fermented foods, nisin is currently the only bacteriocin widely used as a food preservative. Many bacteriocins have been characterized biochemically and genetically, and though there is a basic understanding of their structure–function, biosynthesis, and mode of action, many aspects of these compounds are still

unknown. This article gives an overview of bacteriocin applications, and differentiates bacteriocins from antibiotics. Acomparison of the synthesis, mode of action, resistance and safety of the two types of molecules is covered. Toxicity data exist for only a few bacteriocins, but research and their long-time intentional use strongly suggest that bacteriocins can besafely used.

 @ Amar Babikir Elhussein, Could you please give the reference of the article you are talking about? It seems very interesting. I have a question in safety evaluation of probiotics that one of the requirement said the strain should not produce antibiotic. How can I prove it? I'm confused because the desirable probiotics are the ones that can inhibit pathogens (maybe by means of bacteriocin production), but then it should not produce antibiotics???   

Bacteriocins are antimicrobial peptides produced by certain bacteria, that have little effect on closed organisms for competition at local position and prevention of produced bacteria from external harmful effects,might warrant serious consideration as alternatives to traditional antibiotics. antibiotics are substances produced by some bacteria and fungi that have wide effects against other microorganisms.

Bacteriocins are antimicrobial peptides produced by certain bacteria, that have little effect on closed organisms for competition at local position and prevention of produced bacteria from external harmful effects,might warrant serious consideration as alternatives to traditional antibiotics. antibiotics are substances produced by some bacteria and fungi that have wide effects against other microorganisms.

Article Bacteriocins: Safe, natural antimicrobials for food preservation

I found this information on this paper:

Article Comparison of antibiotics and bacteriocins antibacterial act...

I share with you because I think it is a very complete answer:

Multiple aspects discern bacteriocins from antibiotics:

(i) Bacteriocins are produced on the surface of ribosomes in microbial cells, while antibiotics are primarily secondary metabolites of the cell;

(ii) Bacteriocin producers are insusceptible to the bactericidal agents, unlike producers of antibiotics;

(iii) Bacteriocins can attach to the target cell wall anyplace on the surface, as no specific receptors on the target cell wall apparently exist;

(iv) The mechanism of bacteriocin on target cells is diverse and is associated with the method of pore formation in the outer cell membrane. Bacteriocins bind to cell walls of sensitive microbes, motive ionic imbalances, and produce pores (Morisset and Frère, 2002). Inorganic ions leak the target cells through the created pores and thereby killing them. Antibiotics, on the other hand, can inhibit synthesis of the subcellular processes (cell wall synthesis, intracellular protein production, and DNA and RNA replication) (Svetoch et al., 2011).

Multiple aspects discern bacteriocins from antibiotics; (i) Bacteriocins are produced on the surface of ribosomes in microbial cells, while antibiotics are primarily secondary metabolites of the cell; (ii) Bacteriocin producers are insusceptible to the bactericidal agents, unlike producers of antibiotics; (iii) Bacteriocins can attach to the target cell wall anyplace on the surface, as no specific receptors on the target cell wall apparently exist; (iv) The mechanism of bacteriocin on target cells is diverse and is associated with the method of pore formation in the outer cell membrane. Bacteriocins bind to cell walls of sensitive microbes, motive ionic imbalances, and produce pores (Morisset and Frère, 2002) .

Comparison of antibiotics and bacteriocins antibacterial activity on Xanthomonas citri subsp.citri

Antibiotics are medicines that help stop infections caused by bacteria.

Bacteriocins are ribosomally synthesized bactericidal peptides produced by both gram-positive and gram-negative bacteria, and to a lesser extent by some archaea with antimicrobial properties against different groups of microorganisms

Please have a look at the following links:

Bacteriocin: Article Antibacterial Activities of Bacteriocins: Application in Foo...

Antibiotic:https://en.wikipedia.org/wiki/Antibiotic

The major difference between bacteriocins and antibiotics is that bacteriocins restrict their activity to strains of species related to the producing species and particularly to strains of the same species, antibiotics on the other hand have a wider activity spectrum and even if their activity is restricted this does not show any preferential effect on closely related strains.

Article Bacteriocins Produced by Lactic Acid Bacteria A Review Article

Dear Phụng Dương I agree with Sadanand Pandey

Thanks!

I agree with the answer of Dr. Arvind, in microbiology we have two terms: narrow spectrum antibiotic and wide spectrum antibiotic, so in this case we cane say that bacteriocin is from the narrrow spectrium antibiotics.

The major difference between bacteriocins and antibiotics is that bacteriocins restrict their activity to strains of species related to the producing species and particularly to strains of the same species, antibiotics, on the other hand, have a wider activity spectrum and even if their activity is restricted this does not show any preferential effect on closely related strains (Zacharof and Lovitt, 2012).

Bacteriocins are proteinaceous toxins produced by bacteria to inhibit the growth of similar or closely related bacterial strain(s). ... Antibiotics or antibacterials are a type of antimicrobial used in the treatment and prevention of bacterial infection. They may either kill or inhibit the growth of bacteria. The differences between them are:

1- Bacteriocins are produced on the surface of ribosomes in microbial cells, while antibiotics are primarily secondary metabolites of the cell.

2- Bacteriocin producers are insusceptible to the bactericidal agents, unlike producers of antibiotics.

3- Bacteriocins can attach to the target cell wall anyplace on the surface, as no specific receptors on the target cell wall apparently exist.

4- The mechanism of bacteriocin on target cells is diverse and is associated with the method of pore formation in the outer cell membrane. Bacteriocins bind to cell walls of sensitive microbes, motive ionic imbalances, and produce pores. Inorganic ions leak the target cells through the created pores and thereby killing them. Antibiotics, on the other hand, can inhibit synthesis of the subcellular processes (cell wall synthesis, intracellular protein production, and DNA and RNA replication). Their bactericidal and bacteriostatic mechanisms are diverse and may comprise pore formation, degradation of cellular DNA, disruption via specific cleavage of 16S rRNA, and blockage of peptidoglycan synthesis.