CCl4 induced liver fibrosis, is there another model rather than CCl4.
For a comparison see these reviews:
Experimental liver fibrosis research: update on animal models, legal issues and translational aspects. Liedtke C, Luedde T, Sauerbruch T, Scholten D, Streetz K, Tacke F, Tolba R, Trautwein C, Trebicka J, Weiskirchen R. Fibrogenesis Tissue Repair. 2013 Oct 1;6(1):19. doi: 10.1186/1755-1536-6-19.
Animal models for the study of hepatic fibrosis. Starkel P, Leclercq IA.
Best Pract Res Clin Gastroenterol. 2011 Apr;25(2):319-33. doi: 10.1016/j.bpg.2011.02.004.
Dear Mudhir Sir,
I am listing some of the mouse and rat model which resembles the liver fibrosis desease which seen is human.
Administration of a high-fat diet leard to increase in plasma insulin levels, resulting into development of insulin resistance, causing the metabolic syndrome. Besides panlobular steatosis and strongly enhanced hepatic lipid content, increased transaminases and finally signs of hepatic inflammation and fibrosis were observed in rats after 4 weeks on a high-fat diet.
Cholestatic liver injury one of the model liver fibrosis and cirrhosis in patients with acute or chronic liver disease. Damage to the biliary epithelium and bile duct injury can lead to end-stage liver disease, liver failure, organ transplantation or death.
Dimethylnitrosamine, and Thioacetamide induced liver fibrosis is other good model.
Knockout mouse strain lacking the interleukin 2 receptor, α chain (IL2Rα) gene, also NOD.c3c4 mice congenically derived from the nonobese diabetic strain that develop an autoimmune biliary disease
Feeding mice ANIT is another xenobiotic model to induce cholestatic liver injury.
also I am giving the link which contains information regarding the liver fibrosis which may help you in the finding your answer and may help you in your research
Dear Mudhir,
there are 2 more different fibrosis models which we applied in mice besides CCl4 induction:
Good luck
Özlem
For a comparison see these reviews:
Experimental liver fibrosis research: update on animal models, legal issues and translational aspects. Liedtke C, Luedde T, Sauerbruch T, Scholten D, Streetz K, Tacke F, Tolba R, Trautwein C, Trebicka J, Weiskirchen R. Fibrogenesis Tissue Repair. 2013 Oct 1;6(1):19. doi: 10.1186/1755-1536-6-19.
Animal models for the study of hepatic fibrosis. Starkel P, Leclercq IA.
Best Pract Res Clin Gastroenterol. 2011 Apr;25(2):319-33. doi: 10.1016/j.bpg.2011.02.004.
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