• In truth, any homogeniser as long as it is sold by a medical tech company (e.g. SLS Fisher etc) and not something miscellaneous on (say) amazon is likely to be of standard
• What is important during tissue homogenisation for RNA extraction is keeping everything cold:
• Thus, I routinely snap freeze my tissue in Liquid nitrogen and then homogenise in a lysis buffer which is designed to keep the RNA stable
• Alternatively for small amounts of tissue I have snap frozen and then placed into more liquid nitrogen in a mortar and ground up cold with a pestle before immediately transferring to Lysis buffer on ice and then vigorously pipetting up and down

As what Laurence mentioned, pretty much they are all fine. I personally use the Qiagen TissueLyser II with a steel bead to homogenize mouse liver and adipose tissue. But the key is keeping tissue cold, and working fast

Laurence Stuart Dawkins-Hall Shawn Krueger

Your advice is really helpful. Thank you so much!!

Bertin Precellys has worked well for me (extracting bacterial RNA from human fecal samples).