I am struggling to find any literature that compares the effects of postprandial glucose spikes with elevated glucose (significantly higher iAUC but a lower spike) on metabolic health. Any help would be much appreciated.
Glucose spikes are denderous because of 2 things.
1. Over some value (obout 150 mg/dl) glucose became metabolised through alternative metabolic pathways which results in glucose toxicity. where is higher iAUC but lower spike glucose is metabolised mainly via glycolysis which is good.
2. The higher concentration of glucose in blood the higher ratio of protein glycation.
Oxidative Stress and Diabetic Complications
Ferdinando Giacco, Michael Brownlee 2010
Circ Res. 2010;107:579–591
I agree with Dr Jarzyna. One should ask, "what are the end points for metabolic health? What are optimal heath parameters? "
Dear Ben,
this publication answers your question more or less, the authors show that postprandial glucose is more strongly associated with atherosclerosis than HbA1c (which is a measure for the average glucose of the last 8 weeks).
Temelkova-Kurktschiev TS, Koehler C, Henkel E, Leonhardt W, Fuecker K, Hanefeld 447 M (2000) Postchallenge plasma glucose and glycemic spikes are more strongly 448 associated with atherosclerosis than fasting glucose or HbA1c level. Diabetes Care 23: 449 1830-1834
Kind regards,
Bernard
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