What is the acceptability limit of CV % of intermediate precision ?

in pharmaceutical feild : an anlytical method is valid according to the classical approch (descriptive), when the relative coefficient of variation of intermediate precision is less than 3%. in...

31 December 2018 2,092 0 View

Evaluating data stability Following ICH Q1(E) ?

ICH guidline ask for the justification of presentation of new drug substance, to do so we should follow the ICH Q1(E) guideline, This guideline is destinated to evaluate data stability indeed,...

02 March 2018 522 7 View

Why mean responses are used to define surface response?

in the second (optimisation) step of application of design of experiment, we tried to set a model to define most influential factors"we call too surface response methodology" , in parallel, this...

09 October 2017 8,989 2 View

How can we try the system suitability test ?

my question is about the place of system suitability test in developing and validating a New analytical UPLC Chromatography method. its places is considered as a step in the analytical validation...

09 October 2016 283 10 View

Reversed phase liquid chromatography ?

is reversed phase liquid chromatography used only in gradient elution ? what i know we use in reversed phase liquid chromatography (hydrophobic mobile phase)

09 October 2016 160 10 View

What is System suitability test ?

02 March 2016 9,151 3 View

What they means with Concentration of ion-pair reagent?

10 November 2015 3,854 2 View

The result of measurement of uncertainty of method should big a small?

in each laboratory analyst are obliged to give a state of uncertainty of their measurement, so in this way the value of uncertainty should be so correct to create a certain reliability between...

08 September 2015 4,880 1 View

How can accuracy profile integrate three parameters of validation as linearity, trueness and precision?

05 June 2015 5,687 3 View

How can we define a acceptance limits in validation studies?

02 March 2015 119 6 View

How to compare two groups with only two measurements?

Hiiiii everyone! I have an enquiry on statistical analysis. I was looking for many forum and it's still cannot solve my problem. I want to compare means of two groups of data but only with two...

03 March 2021 8,796 3 View

Enhanced Yellow Fluorescent Protein (Aequorea victoria) DNA sequence?

I am on the lookout for the Enhanced Yellow Fluorescent Protein (Aequorea victoria) DNA sequence. Does anyone know where I can find it? Thank you in advance

03 March 2021 3,568 1 View

What kind of fluid could I use for a pitfall trap that also does not invalidate molecular testing?

Hi, I want to start testing pitfall trap to obtain ants samples, but I need to conduct molecular analysis on those insects. So, what kind of fluid can I use? Ethanol expires too early and I need...

03 March 2021 5,978 5 View

What's the best way to measure growth rates in House sparrow chicks from day 2 to day 10?

What's the best way to measure growth rates in House sparrow chicks from day 2 to day 10? Since, the growth curve from day 2 to 10 won't be like the "Logistic curve" it might not follow logistic...

03 March 2021 1,401 3 View

Do we need to write protocol for a second study of a systematic review that has been registered and published?

I have conducted and published a systematic review and meta-analysis research with the topic related to public health and health pomotion (protocol was registed in PROSPERO). Now we want to...

03 March 2021 8,920 3 View

How to increase a model accuracy ?

dear community, my model is based feature extraction from non stationary signals using discrete Wavelet Transform and then using statistical features then machine learning classifiers in order to...

03 March 2021 6,994 5 View

Do I need to do linear regression before running mediation analysis using PROCESS MACRO by Hayes ?

I just wanted to check if I need to run a linear regression separately if I am using PROCESS MACRO to run mediation analysis. Thank you.

02 March 2021 4,359 3 View

Sample dilution for quantitative analysis using ELISA?

If the detection range is in ng/ml but the reference range is in ug/ml for a molecule or protein in serum or plasma .how to dilute and what is the initial volume to be taken for quantitative analysis

02 March 2021 7,670 3 View

Is There Any Feasible Method To Test Fluorescent Compounds Other Than Fluorescence Spectrometers ??

Is There Any Feasible Method To Test The Efficiency Of Fluorescent Compounds Other Than UV Spectrometers ? Suggestions Would Be Appreciated !

02 March 2021 5,785 3 View

Is there a powerful system for the security of the systems distributed on IoT systems?

Is there a powerful system for the security of the systems distributed on IoT systems?

02 March 2021 3,858 10 View