What is the acceptability limit of CV % of intermediate precision ?

in pharmaceutical feild : an anlytical method is valid according to the classical approch (descriptive), when the relative coefficient of variation of intermediate precision is less than 3%. in...

31 December 2018 2,092 0 View

Evaluating data stability Following ICH Q1(E) ?

ICH guidline ask for the justification of presentation of new drug substance, to do so we should follow the ICH Q1(E) guideline, This guideline is destinated to evaluate data stability indeed,...

02 March 2018 522 7 View

Why mean responses are used to define surface response?

in the second (optimisation) step of application of design of experiment, we tried to set a model to define most influential factors"we call too surface response methodology" , in parallel, this...

09 October 2017 8,989 2 View

How can we try the system suitability test ?

my question is about the place of system suitability test in developing and validating a New analytical UPLC Chromatography method. its places is considered as a step in the analytical validation...

09 October 2016 283 10 View

Reversed phase liquid chromatography ?

is reversed phase liquid chromatography used only in gradient elution ? what i know we use in reversed phase liquid chromatography (hydrophobic mobile phase)

09 October 2016 160 10 View

What is System suitability test ?

02 March 2016 9,151 3 View

What they means with Concentration of ion-pair reagent?

10 November 2015 3,854 2 View

What is Incurred Samples?

09 October 2015 4,080 1 View

The result of measurement of uncertainty of method should big a small?

in each laboratory analyst are obliged to give a state of uncertainty of their measurement, so in this way the value of uncertainty should be so correct to create a certain reliability between...

08 September 2015 4,880 1 View

How can we define a acceptance limits in validation studies?

02 March 2015 119 6 View

How to compare two groups with only two measurements?

Hiiiii everyone! I have an enquiry on statistical analysis. I was looking for many forum and it's still cannot solve my problem. I want to compare means of two groups of data but only with two...

03 March 2021 8,796 3 View

What's the best way to measure growth rates in House sparrow chicks from day 2 to day 10?

What's the best way to measure growth rates in House sparrow chicks from day 2 to day 10? Since, the growth curve from day 2 to 10 won't be like the "Logistic curve" it might not follow logistic...

03 March 2021 1,401 3 View

Is there a powerful system for the security of the systems distributed on IoT systems?

Is there a powerful system for the security of the systems distributed on IoT systems?

02 March 2021 3,858 10 View

How Relativistic effects is one reason for lanthanide contraction?

The Lanthanide contraction which is the decrease in ionic radii of the elements in the lanthanide series from atomic number 57, lanthanum, to 71, lutetium, is due to poor shielding of the 4f...

01 March 2021 2,272 4 View

Benefits of the 24 welled plate?

We have always used the 96 welled plate, the 48 welled plate but apparently there is much evidence on the 24 welled plate and above all its benefits.It states it is the same you would use on ELISA...

28 February 2021 1,149 1 View

For modelling epoxy-based matrices (in composites), which model in ABAQUS is the most suitable, Concrete damaged plasticity or Drucker-Prager model?

I am working on developing a micromechanical FE model for predicting kink-band formation in UD composites. To model matrix plasticity, which model, out of Concrete Damaged Plasticity and...

28 February 2021 5,415 1 View

VIF very high, but correlation is low and coefficient is significant. Which one whould I choose?

Hello. I have a question whether if my coefficients (statistically significant) would be valid when VIFs are really high. In my model, there are independent variables(IV), moderating variables...

26 February 2021 956 13 View

How to compare 2 samples recruited with different sampling methods?

If I want to compare characteristics of 2 groups of patients, one group is recruited from a random sample of the general public while another group is from a sample with a fixed gender (male to...

26 February 2021 3,526 3 View

Can anyone share his experience regards Smoothing in origin?

I am working on TiO2 composite material and the results of XRD have a lot of small/junk peaks and while I apply a smooth filter in Origin then the other characteristics peaks disappear so anyone...

26 February 2021 8,183 3 View

Data Analysis K-S and S-W tests?

Hello, I have conducted analysis where the K-W and S-W have come out as p

25 February 2021 9,648 3 View