Manganese is trace element that is required by human , Manganese is located largely in the mitochondria. It activates numerous enzymes — such as hydrolases, transferases, kinases, and decarboxylases — and is a constituent of some enzymes. One of the most well known manganese metaloen-zyme is pyruvate carboxylase, which catalyzes the conversion of pyruvate to oxalo-acetate.2 Other enzymes include arginase, which is involved in the conversion of the amino acid arginine to urea, and mitochondrial superoxide dismutase (SOD). The structure and function of the mitochondria are therefore particularly affected by manganese status. Manganese activates enzymes associated with fatty acid metabolism and protein synthesis,3 and is involved in neurological function.So what is the role of manganese in human health?
Manganese (Mn) is necessary for a variety of metabolic functions including those involved in normal human development, activation of certain metalloenzymes, energy metabolism, immunological system function, nervous system function, reproductive hormone function, and in antioxidant enzymes that protect cells from damage due to free radicals. Article Manganese in Health and Disease
Manganese may help wound healing.
Article Treatment of chronic wouds with an alginate dressing contain...
Manganese may play a role in glucose homeostasis and renal function.
Article Association of blood manganese level with diabetes and renal...
Manganese is transition element, Manganese is a transition metal with multiple valencies (1, 2, 3, 4, 6 and 7), widely distributed throughout the earth’s crust and present in most plant and animal tissue. As a metal, it is similar to iron and is used industrially in the manufacture of steel, batteries and ceramics. Manganese toxicity among workers in these industries, and in manganese ore miners, is well documented. In addition to its potential for toxicity, manganese is also an essential nutrient. In the human body, it is stored in tissues rich in mitochondria (e.g. the liver and pancreas) and is required for the metabolism of amino acids, proteins, and lipids. Manganese salts have also been used therapeutically, for example in the treatment of psoriasis. Homeostasis of manganese is by faecal elimination with relatively little appearing in the urine. Hence cholestatic liver disease is associated with manganese retention and toxicity [1].
Manganese has role in Parkinson disease, here is the summary of selected research ,as follows,see attached paper
The collective evidence to date suggests that environmental exposure to excessive amounts of manganese (Mn) can cause a neurodegenerative condition known as manganism. It is now also relatively clear that Mn is involved in the pathogenesis of Alzheimer's disease and at least some prion diseases. The potential involvement of Mn in a panel of other neurodegenerative conditions including Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and Batten disease has been suggested and investigated, but the results to date are somewhat inconclusive. Herein, previously reported experimental studies investigating the involvement of Mn in the pathogenesis of these conditions are narratively reviewed.therefore tea is connected to parkinson disease,
This link is very useful
https://www.medicalnewstoday.com/articles/325636
Manganese is a cofactor in enzyme functions
This published work gives insight on the nutrition benefits and deficiency diseases of vitamins and minerals, including manganese
Manganese improves brain function.
Article Manganese action in brain function
Please go through the following link.
http://www.annclinlabsci.org/content/4/6/487.full.pdf
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