What is exact mechanism of metformin for sensitizing the insulin receptors and decreasing the serum glucagon levels?

Metformin a well known agent having multiple uses including the diabetes as a major use various effects has been mentioned in various books but the scientific justification is lacking can any body...

07 August 2018 1,492 6 View

Is there Any known association between family history and acquired aplastic anemia ?

Acquired aplastic anemia is of known itiology like drugs, toxins and radiation therapy but is there any relationship found like positive family history may also result in AAA ?

05 June 2018 5,187 3 View

What is the validity of a research question and who will decide it ?

It has been observed that research questions of low standard are being promoted by some so called researchers . Such questions have nothing to do with the scientific research. What is in your...

04 May 2018 3,630 5 View

What are the advantages and disadvantages of integrated module system of teaching for undergraduate medical students ?

Integrated module system of teaching is being adopted by many universities in the world has some one studied the advantages and disadvantages of this system?

04 May 2018 900 2 View

Can some strategies be made at the breeding sites of mosquito in inhibiting the life cycle of the malarial parasite in the initial stage ?

As we know that the life cycle of malarial parasite consist of 1. Mosquito 2. Human Drugs available so far interfere with the human portion of the life cycle of the parasite my opinion is that is...

01 February 2018 5,631 4 View

Can some one provide the list of Sulfonamide derived groups of drugs other then diuretics and antidiabtic drugs ?

Sulfonamides are the oldest group of antibiotics with still surviving in the market in the real use. They have given birth to many other groups of drugs like diuretics and sulfonulureas (Oral...

01 February 2018 6,887 3 View

How many volumes a journal can publish in a year ?

What is traditional is that a journal produces 1 volume in a year with: 12 issues if it is a monthly journal. 3 issues if it is a quarterly published journal 2 issues if biannually published Few...

31 December 2017 9,185 7 View

What is the difference between the duration of part time and full time Ph.D in your country ?

In our setup(Pakistan) full time Ph. D duration of study is minimum 3 years while it is 6 years for the part time students as per guide line provided by the official governing body (Pakistan...

31 December 2017 5,756 6 View

What is the time duration for any updated edition of a book to get re-updated again ?

I have gone through many updated editions of different books and found that no fixed time duration is present among them few are published with new edition after 3 years and few after 4 years...

31 December 2017 2,452 0 View

Why the recommendation status fluctuates at RG ?

I observed that the recommendation status keeps on fluctuation for example the number is 108 and after some times it goes to 96 or even 90 and with time its again comes up to 100 plus. What I...

10 November 2017 9,805 0 View

Which cell line should we use to perform biological dosimetry experiments?

We are preparing some experiments based on irradiating cells under different conditions in order to evaluate the effects in terms of DNA damage, genetic expression, etc. As our project is...

01 March 2021 3,355 3 View

What is the state of the drug inside solid lipid nanoparticles (SLNs)?

I am a little confuse with the mechanism of solid lipid nanoparticles (SLNs). The main point of encapsulating drugs into SLNs is because some drugs have low solubility in water. Therefore, SLNs...

01 March 2021 3,703 3 View

How does an antibody have full intact antibody + half antibody?

Hello, I was just wondering how does a antibody have full intact antibody + half antibody? Is it because of the drug conjugation?

28 February 2021 1,577 1 View

For modelling epoxy-based matrices (in composites), which model in ABAQUS is the most suitable, Concrete damaged plasticity or Drucker-Prager model?

I am working on developing a micromechanical FE model for predicting kink-band formation in UD composites. To model matrix plasticity, which model, out of Concrete Damaged Plasticity and...

28 February 2021 5,415 1 View

B-mercaptoethanol (BME) protocol?

Hi everybody, I have been running a multiplex IHC which allow me to stain the same tissue with different markers (Primary Ab + Secondary conjugated Ab) (AF487, AF555, AF647). Since I would like to...

27 February 2021 5,028 2 View

How do I choose contrasts in SPM8?

I am learning how to use SPM for PET and PET-MR analysis, but I haven't found any great resources that explain how contrasts work. I have a series of PET images where our hypothesis argues that...

24 February 2021 1,534 2 View

Quantifying leaking DNA from bacteria - what's the secret?

Hi, all! I need to determine if my treatment causes membrane damage in bacteria (S. aureus and E. cloacae), but I cannot use a fluorescent probe such as PI and similar ones because my compound is...

24 February 2021 2,006 2 View

How the Ground Plane implantation is performed without damaging (and w/o varying the undoped nature) the top Si (8-10 nm) in FDSOI technology ?

It is a general practice to introduce Ground Plane in FDSOI devices under the BoX. The Ground Planes are introduced by Ion Implantation through Top Si layer and Buried Oxide. I wanted to know that...

24 February 2021 5,974 4 View

How to Control Whiteflies in coconut leaves?

24 February 2021 1,005 1 View

Any references about insects or animals that can damage or weathering of rock or fossil material?

Are there any references to insects or animals that can cause damage or weathering to the rock or fossil material? books or paper that would be nice. Thank you very much!

24 February 2021 6,805 3 View