How to perform molecular dynamics simulation of Protein-RNA complex at different pH condition??

04 May 2017 8,319 4 View

How do I perform protein-ligand simulation in gromacs with gold atoms?

I want to run protein-Ligand simulation where gold atoms are ligand. Gromacs is showing error for that. I tried to use Prodrug server also, but it is not generating coordinates for gold...

10 November 2015 4,290 7 View

How can I build the virion capsid from single coat protein?

I am having the full-length homotrimer coat protein's predicted model. I want to rebuild virion capsid (Icosahedral virion) by using this homotrimer. Capsid structure of this virion is available...

10 November 2015 9,219 3 View

Can anyone tell me protein's name whose three dimensional structure contains Gold atoms?

10 November 2015 7,672 1 View

Is there any kind of change in pH of cell while it is dying due to viral infection?

31 December 2014 4,222 11 View

How can we calculate the volume of a particular domain in simulation trajectory in gromacs?

I want to check the agonist and antagonist effect of ligands on the same protein by doing simulation studies. Protein functioning is a result of conformational changes in protein structure and...

07 August 2014 5,573 4 View

What is the relation between stability of protein and Gibbs free energy?

If conformational changes are occurring in protein structure then how will it effect Gibbs free energy of that particular protein?

10 November 2013 8,543 14 View

How to predict protein structure along with dsRNA?

I want to model one protein structure along with Double strand RNA molecule. I tried to dock this RNA in protein with the help of HADDOCK server but it is not giving the exact pose which I needed...

07 August 2013 1,636 4 View

How do I infer energy landscape in Dihedral Principle Component analysis in Gromacs?

I am performing MDS to find out conformational changes in protein structure. To verify that result, I have done Dihedral Principle Component analysis (DPCA). I got the result up to energy...

06 July 2013 4,457 0 View

How to do multi-chain and multi-template modeling at same time in modeller?

I want to do multi-chain modeling by using more than one template at one time. How should I do this? Do I need to change model_multiple python script or to change model_multichain script?

05 June 2013 8,949 2 View

How to compare two groups with only two measurements?

Hiiiii everyone! I have an enquiry on statistical analysis. I was looking for many forum and it's still cannot solve my problem. I want to compare means of two groups of data but only with two...

03 March 2021 8,796 3 View

What's the best way to measure growth rates in House sparrow chicks from day 2 to day 10?

What's the best way to measure growth rates in House sparrow chicks from day 2 to day 10? Since, the growth curve from day 2 to 10 won't be like the "Logistic curve" it might not follow logistic...

03 March 2021 1,401 3 View

Does any one know how i can prepare liver tissue with transmission electron microscope with good fixation?

i have problem in preparation of liver tissue with bad cell organelles and how i can adjust osmolarity

03 March 2021 8,890 1 View

I need to image mesoporous silica nanoparticles that are in ~100 nm size and do high resolution TEM to look at mesopores. what grids should I use?

Need to image mesoporous silica nanoparticles using the TEM. Also, need high resolution TEM images to see the mesoporous structure. Kindly suggest what kind of grids to use. Thanks, Shatadru

02 March 2021 1,787 2 View

Is There Any Feasible Method To Test Fluorescent Compounds Other Than Fluorescence Spectrometers ??

Is There Any Feasible Method To Test The Efficiency Of Fluorescent Compounds Other Than UV Spectrometers ? Suggestions Would Be Appreciated !

02 March 2021 5,785 3 View

Do you know any MR image dataset?

I would like to research on MR images (0.5T and 3T). Can you please suggest some websites that I can download dataset including both 0.5T and 3T MR images? Thank you.

02 March 2021 7,735 3 View

Shall I skip the measurement model in SmartPLS?

Hello everyone, I had run a mediation model in SmartPLS using questionnaires that were already validated among my statistical population. A professor who edited my paper -though she is not...

01 March 2021 3,052 3 View

VIF very high, but correlation is low and coefficient is significant. Which one whould I choose?

Hello. I have a question whether if my coefficients (statistically significant) would be valid when VIFs are really high. In my model, there are independent variables(IV), moderating variables...

26 February 2021 956 13 View

SEM or Multiple Regression for an analysis without Latent Variables?

Hello, I have three hypothesis to test, all with the same IV. I am testing if the effect of the IV on the first DV is mediated by awe. I am then measuring whether the effect of the IV on a...

26 February 2021 8,399 5 View

Data Analysis K-S and S-W tests?

Hello, I have conducted analysis where the K-W and S-W have come out as p

25 February 2021 9,648 3 View