What is a rapid model for induction of metabolic syndrome in rat?

More Sina Mahdavifard's questions See All

To what degree does the immunohistochemical (IHC) evaluation of Ki-67 hold diagnostic value beyond neoplastic pathologies?

In the context of doctoral research, I utilized immunohistochemical (IHC) analysis to quantify the expression levels of the Ki-67 proliferation marker. While the application of this test and...

25 June 2024 7,825 2 View

What is the acceptable range of forces required to advance a delivery sheath to crimp a self-expandable nitinol stent for cardiovascular intervention?

Clinicians need to crimp the self-expandable stents into a delivery sheath so they can deploy it at a target site. I want to know if there are any researchers out there discussing the amount and...

17 June 2024 5,279 0 View

What is the typical speed of steering a steerable catheter by a cardiovascular interventionist?

Let’s say a clinician is using a steerable catheter and we want to see the range of velocities the clinician manipulates the steering module with. Are there any references citing this?

17 June 2024 4,289 0 View

What is the acceptable range for movement/deflection of anchoring points (reconfigurable anchor points) for a cable-driven parallel robot/mechanism?

I am working with a cable-driven parallel mechanism where the cables pass through anchoring points and connect to an end-effector manipulated by the user. In my setup, these anchoring points are...

14 May 2024 9,447 0 View

How to extract nitinol's superelastic parameters based on Auricchio's model?

I have done a stress-strain test and it looks like the picture attached. However, in here, I only have upper and lower plateau stresses. In Auricchio's model for the superelastic behavior of...

03 April 2024 9,575 3 View

Stent radial force requried to cause damage to artery wall intima?

I am working on the measurement of radial forces exerted by self-expandable cardiovascular stents. I need to know how much force can damage the intima of arterial walls? Please refer me to a...

31 March 2024 1,774 5 View

What are the best welding configuration for welding a cylindrical tube to a flat surface?

I'm welding (laser welding) a nitinol cylindrical tube to a nitinol flat surface, and I am evaluating three methods for the laser welding configuration (as depicted below): I) using a groove on...

26 March 2024 4,006 6 View

inquiry about adsorption isotherm for a structure with complicated behavior ?

The bio-adsorbent that I'm using has this weird behavior the first question is that I have been reading every quote online saying that non-linear fitting is a way better approach than linear...

07 March 2024 7,115 0 View

Fluid mechanics of air embolism and blood leakage through arterial catheterization interventions?

How can I calculate the risk of air embolism or blood leakage when using a microchannel catheter (polyimide, ID ~ 0.015") in femoral arteries, considering the pressure differences and factors like...

07 March 2024 320 0 View

Are very small or negative p-norm stress sensitivity values expected in global p-norm stress measure?

I'm working on p-norm topology optimization in plane stress using a MATLAB code adapted from the article An efficient 146-line 3D sensitivity analysis code of stress-based topology optimization"...

17 December 2023 1,282 2 View

Can I multiplex a mouse monoclonal and rat primary for IHC (mouse brain tissue)?

Hi all, I was just wondering if anyone has experience with multiplexing a mouse monoclonal primary and a rat primary. I'm trying to multiplex by incubating them in the same well but was told by a...

06 August 2024 9,710 1 View

In what part of the brain´s rabbit bdnf is located and include references please?

I´ve been unable to find specific information about this neurotrophin in the CNS of rabbits exclusively. There is extensive info in mice, fish and rats, but in brain´s rabbit is hard to find....

04 August 2024 762 1 View

What can be the minimum number of animals (rats) to be used for a pilot/preliminary study on intradermal drug delivery?

Dear All I would like to know the minimum number of animals (rats) to be studied for a pilot/preliminary research on intradermal drug delivery. Can I proceed with 1 animal per group for a pilot work?

02 August 2024 4,570 1 View

How are aPTT and PT values reduced after hemodialysis compared to before dialysis value in patients with chronic kidney disease?

I am conducting my research regarding blood coagulation in patients with CKD. I observed a reduction in post hemodialysis aPTT and PT values compared to pre hemodialysis values. But most of...

30 July 2024 3,467 0 View

CAD File of human's & rat's respiratory airways ?

Dear all, I am working on particle deposition in human's & rat's respiratory airways using CFD and I am looking for the 3D CAD file for my simulations (STEP or IGES format). If somone has such...

29 July 2024 1,092 2 View

Could GSH level be more in CCL4 rats than negative control rats?

i compare between the antioxidant and oxidative stress level between negative control rats (saline) and CCL4 intoxicated rats. i found the level of GSH and TAC is more in toxic group than normal....

26 July 2024 1,887 0 View

Unexpected 35 kDa Band Observed During Expression and Purification of Dengue 3 NS5 RdRp Domain ?

Background: I am developing an RdRp assay for Dengue virus-3 and need to express and isolate the NS5 protein's RdRp domain (~101 kDa). My expression vector includes a GST tag followed by a 6x His...

13 July 2024 9,950 3 View

What is the anti anaemic potentials of hibiscus sabdariffa on wister rats?

anti anaemic potentials if hibiscus sabdariffa

01 July 2024 8,429 0 View

What is the best method to measure diameter of new vessels in tissue,e.g. spinal cord?

Hello! I would like to study newly formed vessels after spinal cord injury in rats. However, I do not know what is the most suitable method to check diameter or number of vessels and which...

01 July 2024 9,744 0 View

Can I do IPTG induction on OD600=2.6 in TB?

I have been looking at papers for protein expression and trying to follow the process. I'm using TB medium to do the process, and the paper says to grow to an OD600 = 1.8 at 37 degrees, then let...

30 June 2024 6,502 5 View

Anand Ramasamy

I think the the below link will give you an idea about the induction of metabolic syndrome

Article Animal models of metabolic syndrome: a review

Justin Siemian

Streptozotocin is commonly used to induce diabetes in rodents.

Md. Shahed-Al-Mahmud

Hello Mahdavifard,

In my opinion, Glucocorticoid-induced is the rapid model for analyzing metabolic syndrome in rats. This model has some benefits because it acting directly on different tissues and organs through the different mechanism in rats.