Reye's syndrome is known to have catastrophic complications including fulminant liver failure and brain damage in genetically susceptible individuals (with inborn errors of metabolism, especially fatty acid oxygenation). Viral infection is the most common trigger, however is not essential, rather the metabolic changes that take place resulting in hyperammonemia and other toxicities are the basis for the pathogenesis. The disease is very rare these days as aspirin is never prescribed to children except in the case of Kawasaki Disease.
Зовсім невірно надавати дітям з цим захворюванням Aspirin . Для зниження температури як в при синдромі Рея, так і в інших випадках рекомендую препарати парацетамола, його похідних або індуктори інтерферона з гіпотемпературним ефефктом, хочаб такий препарат , як мефенамінова кислота. Також бажано в проміжках між прийомом ліків застосовувати сорбентотерапію
Reye’s syndrome is a rare but serious disease that causes swelling in the liver and brain. It can affect people of any age, but it is most often seen in children and teenagers recovering from a virus such as the flu or chickenpox.
Studies have found that the main risk factor for Reye’s syndrome is taking aspirin or other related drugs, called salicylates.
Because of this, doctors recommend that children and teenagers recovering from viral infections should avoid taking aspirin
O. Raksha-Slusareva Allow me, I translated your answer into English
It is completely wrong to give children with this disease aspirin. To reduce the temperature of the Ray syndrome, and in other cases, I recommend preparations of paracetamol, its derivatives or interferon inducers with a hypothermic effect, although there is such a preparation as mefenamino acid. It is also desirable to use sorbent therapy between medicines
Reye’s syndrome is a rare, but extremely serious condition that affects children and teenagers recovering from viral illness such as the flu or chickenpox. It most commonly causes swelling of the brain and a large build up of fat in the liver. Rapid breathing, diarrhoea, continuous vomiting, irritable or aggressive behaviour excessive lethargy and decreased level of consciousness are some of the symptoms of Reye’s syndrome. The exact cause of Reye’s syndrome is not known, however links have been made between patients with an underlying fatty acid oxidation disorder and taking aspirin during viral infections. Please take a look at the following links for more details.
Article Reye's syndrome.
Article Reye Syndrome - A Case Report with Review of Literature