Hi Satadru, maybe this will be helpful for you: https://www.researchgate.net/publication/316199088_A_cleanup_method_using_solid_phase_extraction_for_the_determination_of_organosulfur_compounds_in_petroleum_asphalt_cements
Article A cleanup method using solid phase extraction for the determ...
I'm pretty sure Bill Letter will comment on that question, but as usual the problem for such HPLC questions is that you do not provide any details on your measurement conditions - which solvent system, gradient, column etc. you use. Otherwise we can not help you. I also do not get the point what exactly you want - separation, purification at which scale?
Depends on the solubility of your target molecules and the sample matrix (since HPLC is a branch of liquid chromatography). I would think organic solvents like Methanol, Acetonitrile, IPA...