We are going to conduct a study on the antidiabetic activity of sea urchin extracts and it was suggested that we use cell lines to determine the activity of our extract. Are there any laboratories where we can get these cell lines? Or what alternative in vivo or ex vivo methods can be used instead of cell lines?
Hello Kiana Florentino,
In vivo models for investigation of antidiabetic activity of bioactive substances always have the problem of long experimental cycle, complicated experiment, and high cost. Compared with the animal models, cell culture could be much more quicker, simple and economical.
You may want to refer to the article attached below which provides different types of in vitro diabetic cell model.
https://doi.org/10.1002/efd2.38
The cell lines may be obtained from
ATCC
https://www.atcc.org/about-us?matchtype=&network=x&device=c&adposition=&keyword=&gad_source=1&gclid=EAIaIQobChMIj6Xk6cLJhAMV_20PAh1KtwHSEAAYASAAEgIgtfD_BwE
or
ECACC
https://www.ukbrcn.org/who-we-are/european-collection-of-authenticated-cell-cultures-ecacc/
Good Luck!
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