The samples that we're using consist of a hydrophobic drug compound and a nanopolymer (PEG-siPMNT). We synthesized it by dialysis in DW as the following step: dissolve drug in DMF, then add the polymer and TEOS, mixed well. Following by loading into the dialysis bag. DW was changed in 4hr, 8hr, 12hr and 18hr. Collected samples were supposed to be a water soluble nanoformulated solution. Instead, we yieled a gel-like state (as shown).
We wanted to be clear on which factor caused the gelation. Many attemps before yield expected results, but the gelation has become more frequent from time to time.
Sorry for my terible English. We wish you a great day!
If the result of the process is changing over time, without changing anything about it deliberately, then the likeliest reason for the problem is that one or more of the ingredients is unstable. Try the process again with fresh batches of the ingredients.
You should do this experiment in a more diluted solution. For example, 100 times
I think it is not completely stabilized because of incomplete polymerization. The stability of polymer is depends on the solvents used for synthesis, synthesis method ,chemical nature of initial reactants and surrounding environment. You should choose the proper solution for synthesis like acetonitrile.
(Lan et al., 2015; Wu and Morbidelli, 2014).
Best of luck
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