As you know well, PPAR-delta, also referred to as PPAR-beta, promotes the beta-oxidation of free fatty acids, increases the number of mitochondria, anti-obesity, the attenuation of insulin-resistance. PPAR-delta directly or indirectly activates the transcription of the following genes, respectively.

• Lipoprotein lipase（LPL）

• PGAR（FIAF/ANGPTL4）

• Integrin-linked kinase（IDK）

• 3-phosphoinositide-dependent kinase-1（PDK-1）

• Ubiquitin C

• carnitine palmitoyltransferase 1 (CPT1)

• acyl-CoA oxidase (AOX)

• long chain acyl-CoA dehydrogenase (LCAD)

• uncoupling protein 1 (UCP1) and UCP3 (for thermogenesis/energy dissipation)

• PGC1-alpha (which contributes to mictochoriagenesis)

Furthermore, it is highly likely that PPAR-delta directly or indirectly activates the transcriptional factors such as, PPAR-gamma, adiponectine etc, in cooperation with retinoic acid receptor (RXR). PPARδ/RXR heterodimers bind to the DR-1 type response elements with a core sequence AGGTCA on target gene promoters and turn on transcription upon ligand activation. I think it is also important to note the crosstalk between AMPK signal pathway and PPAR-delta is important for the maintenance of metabolic axis.

Ref

• FEBS Lett. Jan 9, 2008; 582(1): 26–31.

Hi Go J Yoshida. Thanks a lot for your reply. It is very useful for me.

Hi,

You can find this information at the KEGG database.