According to a journal about complications of donor apheresis, although reactions during apheresis are significantly less than whole blood donation, complications such as citrate reaction may still arise. The infusion of citrate anticoagulant during apheresis will cause the binding of calcium to the citrate. As a consequence, the patient may experience hypocalcemia or lower ionized calcium levels which will then lead to neuromuscular hyperactivity.

Winters, J. L. (2006). Complications of donor apheresis. Journal of Clinical Apheresis, 21(2), 132–141. https://doi.org/10.1002/jca.20039

Procedures involving apheresis are typically highly received. During or after the procedure, adverse events of varying degrees of severity could happen. There are two types of reactions that it causes in donors: local reactions and systemic reactions. Hematomas from extravasation from the veins brought on by improper needle positioning during venipuncture are the most common local responses. At the extravasation location, discomfort, hyperemia, and edema could appear. Localized thrombophlebitis and phlebitis are extremely rare. Vasovagal reactions, which make up the majority of systemic reactions, can be brought on by venipuncture discomfort, stress associated with donating blood, etc. They are characterized by pallor, perspiration, nausea, dizziness, bradycardia, hypotension, and syncope. The use of acid-citrate-dextrose (ACD) in apheresis results in citrate toxicity.

Philip, Joseph, et al. “Adverse Events Associated with Apheresis Procedures: Incidence and Relative Frequency.” Asian Journal of Transfusion Science, vol. 7, no. 1, 2013, pp. 37–41, www.ncbi.nlm.nih.gov/pmc/articles/PMC3613659/#:~:text=%5B1%2C2%2C6%5D, https://doi.org/10.4103/0973-6247.106730.