Dear Dr. Hassan
There are many causes of vaccine failure including
1- Vaccination Program :Each region typically has its own specific diseases .
2- Administration and Handling of the Vaccine:
A well designed vaccination program will not be effective if the vaccine is damaged by improper handling prior to administration. Live vaccines can be inactivated when exposed to adverse conditions.
3- Improper vaccine administration of the vaccine is the most common cause of vaccine failure in poultry.
4- The immune status of the breeder flock can have an affect on the success of progeny vaccination
5- Stress may reduce the chicken's ability to mount an immune response
6- Chickens may also already be incubating the disease at the time of vaccination. Despite proper administration .
7- Vaccine Quality
8- Many diseases are caused by agents that consist of several different strains/serotypes. For example, there are more than 100 recognized strains of IBV .
and another causes.
best wishes and kindly regards
Hi Dr.
In addition to general factors that cause failure in vaccination programme, it may be due to local strain variation.
Regards.
Dear Hassan
There are many points contributed in the failure case, please read in the following link :
https://edis.ifas.ufl.edu/pdffiles/VM/VM13600.pdf
Good Luck
Dear Hassan,
There are majority of reasons against IB vaccine failure, but the essentials/common are the below:
1. Variation in the strain of virus, as we repeatedly administered the same strain of vaccine but haven't researched the variation in the strain of virus, that why resistant created.
2. Improper administration of vaccine
3. Vaccine quality
4. Proper time / schedule due on region, not same everywhere
Maybe more reasons when fully investigate the problem...
Thank you,
Hamdard
Dear
A.R.A. AL-Aqaby
Khalid Hassan
Enayatullah Hamdard
I'm grateful for this answers
thank you
Dear
Dr. Aamer
Dr. Heba
Dr. Alaa
so Dr. Monyer
I'm grateful for their answers
regards
Vaccines are used to prevent or reduce problems that can occur when a poultry flock is exposed to field disease organisms. Vaccinations should be thought of as insurance. Like insurance, there is a price to be paid for protection against a potential threat. Costs include price of the vaccine, time spent designing the vaccination schedule and administering the vaccines, and losses due to vaccine reactions from the live-type vaccines and localized tissue damage from killed-type vaccine injections.
Dear
In general failure of vaccination refer to error of defect in one o f three factors or in all ( host , vaccine , worker ) in many details
dear Dr.Hassan
In general successful vaccination depend upon choosing perfect time ,route and strain as well as experience of team that apply the vaccine
there are some factors affect on vaccine failure, the first one is storage condition of vaccine before use and the reality uses method of vaccine
Dear Dr.
Qassim Kshash
Jinan Abdulrahman
I'm grateful for their answers.
thanks a lot
Almost all the relevant points are covered, except one. It is immuno suppression due infection of any other immunosuppressive organisms( like Infectious Bursal Disease) or due to other non infective reasons( like Inbreeding Depression).
Thanks
Hi
Very good and important and practical question.
I think that the answer of Dr Al-Arai is fairly enough.
Many thanks and regards
Dear Dr. Hassan
There are many causes of vaccine failure including
1- Vaccination Program :Each region typically has its own specific diseases .
2- Administration and Handling of the Vaccine:
A well designed vaccination program will not be effective if the vaccine is damaged by improper handling prior to administration. Live vaccines can be inactivated when exposed to adverse conditions.
3- Improper vaccine administration of the vaccine is the most common cause of vaccine failure in poultry.
4- The immune status of the breeder flock can have an affect on the success of progeny vaccination
5- Stress may reduce the chicken's ability to mount an immune response
6- Chickens may also already be incubating the disease at the time of vaccination. Despite proper administration .
7- Vaccine Quality
8- Many diseases are caused by agents that consist of several different strains/serotypes. For example, there are more than 100 recognized strains of IBV .
and another causes.
best wishes and kindly regards
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