Sequences of mRNA vaccines?

17 April 2024 1 619 Report

For my project I am looking for the mRNA sequences of mRNA vaccines that are currently undergoing clinical trails or that are already in use. I know that the sequences of two Covid-19 vaccines are publicly available (https://github.com/NAalytics/Assemblies-of-putative-SARS-CoV2-spike-encoding-mRNA-sequences-for-vaccines-BNT-162b2-and-mRNA-1273/blob/main/Assemblies%20of%20putative%20SARS-CoV2-spike-encoding%20mRNA%20sequences%20for%20vaccines%20BNT-162b2%20and%20mRNA-1273.docx.pdf). Would anyone have sequence information of other mRNA vaccines or know where to find it?

Kais Khudhair al Hadrawi

mRNA vaccines work by providing the body's cells with instructions to produce a harmless piece of the virus, which then triggers an immune response. The sequence of events in administering mRNA vaccines typically involves several steps:

Design and Synthesis: Scientists identify the genetic sequence of the target virus, such as SARS-CoV-2 for COVID-19. They then design a synthetic mRNA sequence that codes for a part of the virus, usually the spike protein. This mRNA is synthesized in the laboratory.

Encapsulation in Lipid Nanoparticles: The synthesized mRNA is encapsulated in lipid nanoparticles. These nanoparticles protect the mRNA and help deliver it into cells.

Administration: The mRNA vaccine is administered through injection, usually into the muscle tissue.

Cellular Uptake: Once injected, the lipid nanoparticles containing the mRNA are taken up by cells near the injection site, typically muscle cells.

Translation: Within the cell, the mRNA is translated by cellular machinery to produce the viral protein encoded by the mRNA, such as the spike protein of SARS-CoV-2.

Immune Response: The produced viral protein is displayed on the surface of the cell, triggering an immune response. The immune system recognizes the protein as foreign and mounts an immune response, including the production of antibodies and activation of T cells.

Memory Formation: After the immune response, memory cells are formed, which remember the virus and enable a rapid and effective response if the person is exposed to the actual virus in the future.

The specific mRNA sequence used in each vaccine will depend on the target virus and the part of the virus that the vaccine aims to generate an immune response against. For example, in the case of the COVID-19 vaccines developed by Pfizer-BioNTech and Moderna, the mRNA sequence codes for the spike protein of the SARS-CoV-2 virus.

Badges
Science topic

More Bram Verhagen's questions See All

How to model the effect of an individual level variable on a group level variable?

My research question is: do parents with low SES have a higher chance to send their child to a lower quality daycare service? Data have been gathered among parents (>3000) whose child...

14 June 2020 2,876 1 View

Can you stain live/dead cells in 3D tissue culture?

Hi Everyone, I am optimising a ex-vivo 3D culture of human tissues of +/- 300 um thickness. We want to know how many cells are alive and how many are dead at specific timepoints. I know I could...

03 December 2019 625 3 View

Why using Tobit regressions with payout variables?

Hello everyone, For my dissertation I want to measure the impact of CEO and CFO compensation on payout policy. One of the measures I use for payout policy is cash dividends scaled by total...

23 May 2019 5,092 1 View

Mancova with nominal covariates?

16 January 2017 5,567 1 View

To what extent does the variation in VCEon of the dies in IGBT modules require the need of calibration to use it as a TSEP?

For my research on the topic of power cycling capability of IGBT modules, I need to measure the junction temperature of the IGBT dies inside the module. To acquire this temperature measurement, I...

06 October 2014 5,000 1 View

Is there any out there that could help me with any suggestions as to why this us?

I would like to hear from people with interest in this project or Artificial Intelligence and Biometrics Systems

01 January 1970 8,172 8 View

SDS page software for analysis?

I did sds page to determine the difference in protein expression between 3 types of vaccine , but i don't have scanner or densitometer available. . so i wonder if there is a software to analyze...

02 March 2021 6,270 3 View

Which of the Covid-19 Vaccines would elicit the best immunoprotection and why?

I want to know which of the available Covid-19 Vaccines would elicit the best immunological response and why

02 March 2021 1,388 3 View

Is the sinovac vaccine safe and effective for people over the age of 60 ?

Dear respective researchers, I was asked by my institution to be vaccinated this week using the sinovac vaccine. However, from some of the information I got, this vaccine is not recommended for...

01 March 2021 7,781 6 View

How vaccines of covid 19 work?

Millions ask how vaccines of covid 19 be successful and safe, its here to explain generally how vaccine of pfizer work ,mRNA vaccines teach our cells how to make a protein that will trigger an...

28 February 2021 2,723 4 View

Where can I find public datasets with Covid-19 patient information?

Hi, I'm looking for public datasets that have CT, X-ray information, or medical records for patients with Covid-19. Does anyone have suggestions?

28 February 2021 4,760 3 View

Is there any published or unpublished statistics on dropout rate (Dose1 to Dose-2) for Covid-19 vaccination in India, US, UK or any other country?

Are there any published or unpublished statistics or papers on the dropout rate (Dose1 to Dose-2) for Covid-19 vaccination in India, USA, UK, or any other country where vaccination has started at...

28 February 2021 4,237 1 View

What is the most common number of epitopes in an multi-epitope Vaccine?

hi everyone, I'm interested in the field of vaccine design specifically multi-epitope cancer vaccines , I want to know if there is a minimum and maximum number of epitopes we could use in a...

27 February 2021 3,882 3 View

If a given country passes mandatory 'vaccine passport rule' to go outdoors, otherwise stay at home, can it help to vaccinate all against COVID-19?

Wether vaccine passport declared not to go out of home without it may help taking COVID-19 vaccine. Can't it break individual's right to protect the community? Your comments on perspectives...

27 February 2021 5,549 23 View

How long do vaccines protect us against COVID 19?

Or will we have to get vaccinated every year, as in the case of influenza?

27 February 2021 1,048 5 View

Why is the efficiency of viral mRNA electroporation in PBMC low?

Hello, I have been struggling with the electroporation of PBMC with HIV-I mRNA. Although the quality of the RNA generated is good, and the handling of the cells in meticulous, the frequency of...

27 February 2021 9,233 3 View