Aging is a progressive loss of physiological integrity, leading to increased vulnerability to death. Scientists describe 9-10 tentative hallmarks that represent common denominators of aging in different organisms....and senescence is one of the hallmarks of aging.....For detail I would suggest you to read the following review article...

http://ac.els-cdn.com/S0092867413006454/1-s2.0-S0092867413006454-main.pdf?_tid=db88120e-e6ec-11e2-bbbd-00000aacb35d&acdnat=1373191754_d05ed27f5da2765d9cc6fd5216d063ae

Senescence is the shortening of the telomers that results in cell aging..

In my opinion we have "senescence" not "cell senescence"... so, cell aging leds to senescence... such as fruit senescence...

Thanks, but for single cell microorganisms, like bacteria, senescence is meaningful in cell level. isnt it?

Perhaps it is better tell : "cell aging" refered from born to death of cell but "cell senscence" refered to end of cell life... So sensence is the final step of cell aging leads to death of cell.

Aging is a progressive loss of physiological integrity, leading to increased vulnerability to death. Scientists describe 9-10 tentative hallmarks that represent common denominators of aging in different organisms....and senescence is one of the hallmarks of aging.....For detail I would suggest you to read the following review article...

http://ac.els-cdn.com/S0092867413006454/1-s2.0-S0092867413006454-main.pdf?_tid=db88120e-e6ec-11e2-bbbd-00000aacb35d&acdnat=1373191754_d05ed27f5da2765d9cc6fd5216d063ae

@ Sajedeh, Do You know how these two terms are called sceintifically in Persian?

Maybe, with a better scientific translation, they make more senses to me.

Aging: Pir shodan? senescence: koholat?

Thanks Muhammad

Aging consist of all the degenerative changes that occur in time without reference to death as a consequence. Aging takes place during the entire life span of an organism, whereas senescence is considered the final developmental phase that culminates in death

"senescence": piri

"cell aging": pir shodan... Albate cell aging ro ziad motmaen nistam...

During the storage of kind of product (suppose a kind of dried fruit, or a kind of dried cells), cells go through a path that result in progressive inabilities (degenerative changes = aging), they then reach to a phase which is called senescence. In this phase, the cells are subjected to more lethal changes that results in death.

Is this kind of description correct?

Senescence is final developmental phase that take place after overripe in fruit but ageing can occur in each of stage of fruit life cycle e.g. Cell elongation.

OK, I got it. Thanks.

In culture, Ageing is the loss of efficient cellular function & response to environment, while Senescence is the loss of replicative capacity. Usually there is an associated shortening of telomeres. For the organism, in my opinion these definitions may apply as well. Physiologically, senescence may occur during ageing & well before death.

Hello,

Can this definition be generalized to the any environmental stress that stops replication?

For example, during stationary phase because of accumulation of inhibitory compounds, the growth of most bacteria are arrested and then they are not able to do replication. This is called conditional senescence.

Now, if we keep freeze-dried bacteria under some storage conditions for a while, and then some of the bacteria lose their replication capacity, can we call it cell senescence during storage?

My thought would be that this is an induced phenomenon of cell damage due to the freeze-drying & thawing, similar to the conditional senescence from inhibitory compounds or damage from overoxygenation. Severe conditions may more rapidly lead to loss of replicative capacity and apoptosis.

It would depent on the cellular context. Aging in general cell biology includes shortening telomers and increasing DNA damage. A nice article answering your question is "Four faces of cellular senescence"

Both terms are used interchangeably. Aging leads to senescence. But remember, both these phenomena can either be physiological or induced.

Good question. Many people think both terms are the same. Cell senescence is actually a change in cell state that can be independent of age (oncogene induced senescence/ stress induced senescence) or correlated with age (replicative senescence). A senescent cell is in no way an aged cell. Cell ageing refers to the accumulative changes within cells over time that lead to a decline in cellular function.

Hello.

You mean that a young cell may undergo senescence for example because of stress?

Cells of any age can undergo senescence. In fact, this probably occurs throughout our life, but are removed by our immune system. Its only later with age that they may start to accumulate, either because the rate of senescent cell formation is increased and/or an ageing immune system fails to remove them.

hi,

this file is related to your question.

part II. page:181

Hello,

Thanks, Ms. Ameri

That is a great help.

Maybe this will help....

"Cell Senescence" verses "Cell Ageing": What is the Difference?

https://cellsen.wixsite.com/senescentcell/single-post/2017/04/10/Cell-Senescence-verses-Cell-Ageing-What-is-the-Difference

Dominick G.A Burton Great answer Sir, I really appreciate it, real conceptually clear. i worked on aging but i was confused but you really made it so clear. Hatts of to you sir. I want to ask " is senescence is related to morphological changes or physiological or biochemical or genetic changes as well ? Also from your answer what is get is senescence is related to cellular level but when senecenes starts to effect the normal functionality of tissues or organs of the body is called as aging am i right?