What are the details of the reaction in which the polyketide lipid toxin mycolactone activates the production of reactive oxygen species(ROS) to cause necrosis of the skin?

08 August 2012 0 3K Report

The molecule has been identified to have a structure C_(44)H_(10)O_(9). This reaction produces superoxide anion, hydroxyl radical, hydrogen peroxide etc. When ROS exceed certain levels they become toxic. I want to develop a mathematical model for the diffusion of this toxin in the cell and later extend it to the layered skin structure. Mycolactone has been identified as the main virulence for the Buruli Ulcer disease

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