According to this literature ( Cytotoxic Activity and Chemical Composition of the Root Extract from the Mexican Species Linum scabrellum: Mechanism of Action of the Active Compound 6-Methoxypodophyllotoxin. ) Extracts with IC50 ≤ 20 μg/mL and compounds with IC50 ≤ 4 μg/mL were considered active according to the National Cancer Institute (NCI) guidelines .
There are publications that accept 30ug / ml and below for the extract.
How about your ideas, what is the most update ıc 50 values both extract and compund (molecule) , and what is your decision about using commercially available chemotherapeutic as a positive control in MTT experiments?
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