is it related to the action of hypnozoite , which is known as dormant liver stage, I think its a liver stage but its not dormant it has a action affect the action of insulin or glucagon hormones.
The disease malaria and diabetes are major health problems in the society of developing world and both are considered as challenging health problems globally. It is documented that Malaria infection is more common in diabetics specially type-2 diabetes mellitus. However, the direct relationship between these two clinical entities still has not been evaluated. Please go through the following references for regarding their explanation.
1. Danquah I, Bedu-Addo G, Mockenhaupt FP. Type 2 diabetes mellitus and increased risk for malaria infection. Emerg Infect Dis. 2010; 16: 1601-4.
2. Kochar DK, Das A, Kochar SK, Saxena V, Sirohi P, Garg S, et al. Severe Plasmodium vivax malaria: a report on serial cases from Bikaner in northwestern India. Am J Trop Med Hyg. 2009; 80: 194-8
3. Santana MS, Monteiro WM, Costa MR, Sampaio VS, Brito MA, Lacerda MV, et al. High frequency of diabetes and impaired fasting glucose in patients with glucose-6-phosphate dehydrogenase deficiency in the Western Brazilian Amazon. Am J Trop Med Hyg. 2014; 91: 74-6.
4. Pakpour N, Cheung KW, Luckhart S. Enhanced transmission of malaria parasites to mosquitoes in a murine model of type 2 diabetes. Malar J. 2016; 15: 231.
5. 25. Patade GR, Marita AR. Metformin: A Journey from countryside to the bedside. J Obesity Metabolic Res. 2014; 1: 127.
Malaria parasites also are dependent on glucose as a nutrient source. As Plasmodium has no capacity to store energy in the form of glycogen they rely entirely on an exogenous supply of glucose. The infected erythrocyte exhibits a substantial increase in its permeability to low molecular weight sugar. The metabolism of the parasite utilizes up to 75 times more glucose than uninfected erythrocytes. Glucose is vital for Plasmodium. Hypoglycemia is a common clinical problem in neonates, is less common in infants and toddlers, and is rare in older children.