The PH of solution containing magnetic nanoparticles for applications in medical diagnostics and treatment and drug delivery how should it be?
Could you plz specify which type of application of the magnetic nanoparticles? in diagnostics ? in therapy? others? which one?
Dear abbas,
Your question is very general and i think there is no strict answer.
About pH of Nano-particle in order to biological application, we can consider two type of aqueous pH. Acidity of solution during nano-particle synthesis/preparation. This pH is very large range. You can prepare e.g ferric nano-particle in aqueous solution with very low pH around pH=2 and vise verse, in alkaline solution too.
But the second pH is related to application media (biological application), which related to after nano-particle synthesis and related to nano-particle usage and applications.
In this situation you will encounter thre media (in vivo and in vitro and ex vivo).
For in vivo media, you have to adjust a restrict pH around physiological pH (around 7.4).
For ex vivo media you have only small wider range than physiological pH because some cell line can tolerate a small higher pH variation.
But for in vitro media such as nano-diagnostic, again depends on method, samples,..you will have a more wide range option for pH.
finally if your mean is a bout specific example, please let me know for more information.
best
mehdi
The pH for in vivo application, when intravenously, is 7.4, the same as the blood. Different pH would case some problems, like hemodinamics changes or in some cases even death.
i think in addition to nano particle type its dependent on your drug performance PH range and in vitro conditions ..as you know the biologic PH range is 6.5-7.4..
Folks, it seems the question has been misread. It is about the pH of the SOLUTION (probably really dispersion, not solution) of NPs. The NPs themselves may be ANY pH. But when added to the carrier, the FINAL solution pH is what is important. NPs with surface -COOH are considered acidic, right? So in water, the pH may be around 4. But we can instead use a buffer and get nearly any pH value of this buffered NP dispersion.
In addition, it is common for many types of NPs to be encapsulated in some manner, preventing the surroundings from "sensing" them. In the case of magnetic NPs,they may remain unmodified and then be added to a carrier, or they can be surface modified or encapsulated before adding to the carrier.
So really, the discussion needs to be about the manner in which the NPs will be administered to be able to determine what the pH of the product should be. Intravenous use versus interperitoneal injection could have very different pH values for the product.
Dear abbas,
The PH of solution containing magnetic nanoparticles for biological applications should be 7.4 (physiological pH). For in vivo applications, also is necessary physiological salt conditions. PBS (phosphate buffered saline) is the best option.
best,
Antonio
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