I have some queries regarding dispersion of ZnO NPs by ultrasonication and also solvents used for dispersion, like DMSO, ethanol, etc.,
- 1. Dispersion by ultrasonication
Upon synthesizing zinc oxide nanoparticles (ZnO NPs) through either green or chemical methods, the resultant particle sizes are typically in the nano-scale range (nm). However, the size of the synthesized ZnO NPs may undergo alterations during the dispersion process through ultrasonication, deviating from the originally obtained sizes. How can one claim the antimicribial activity of originally synthesized sizes?
- 2. Dispersion by Solvents
The solvents used for the dispersion of ZnO nanoparticles may possess inherent antimicrobial activity, resulting in a synergistic effect when combined with the nanoparticles as opposed to their individual activities.
It is preferable to use the nanoparticles as dispersed in the dispersion media of the synthesis, together with the stabilizers used. Every change in dispersion media likely will lead to destabilization because the stabilizer, solvation layer around the particles is less compatible with the dispersion media.
Ultrasonication may disperse agglomerated particles, but may induce also agglomeration. Using solvents deactivating or killing microbes you do not need nanoparticles with antimicrobial activity, which work usually in aqueous media, often through ions released.
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