The best chemotherapy method in colorectal cancer-bearing mice?

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Malcolm Nobre

Hello Mahmoud Delphan

You could use oxaliplatin (OXA) which not only induces tumor cell apoptosis but can also cause immunogenic death. For more information you may want to refer to the paper I have attached below for your reference.

Article Inhibition of Indoleamine 2, 3-dioxygenase 1 synergizes with...

The investigators employed a xenograft tumor mouse model and confirmed the improved anti-tumor efficacy of OXA against murine colorectal cancer in immune-intact host (BALB/c mice).

The murine colorectal cancer (CRC) model was established with subcutaneous inoculation of CT26 cells. OXA was administered every 3 days for a consecutive four times after xenograft tumor volume reached 50 mm^3, and both tumor growth and overall mouse survival were monitored regularly.

They observed that treatment with OXA significantly delayed xenograft tumor progression in wild-type BALB/c mice in comparison with the vehicle.

Therefore, their data demonstrated that OXA greatly prolonged the overall survival of tumor-bearing wild-type BALB/c mice, and this improved therapeutic efficacy of OXA was dependent on the intact immune system.

Best.