Dear RG users greetings,
It is clear that T cells must encounter antigen in the context of antigen-presenting cells such as dendritic cells, that provide co-stimulatory signals for their activation. However, tumors are essentially invisible to T cells as they are just self modified cells. So, how the T cell activation pathway is working to recognize tumors?
Looking for clarification from experts,
Thanks
T-c ell “induced- self” MHC class I/pep de complexes may enable “de novo” tolerance induc on to neo- an gens occurring outside of the thymus
Lessons from the hair follicle
Tumors have mutated proteins which can be recognized by the immune system. Specifically, DC and macrophages can recognize aberrant protein fragments and get activated...after recognition and activation, they migrate to the lymphonode and activate specific t cells which will then migrate back to the tumor site and kill cancer cells espressing the specific mutated protein.