In a 40 y. old patient with a clinical picture suspect for lymphoma (skin rash, articular pains and edema, fatigue, fever), showing multiple lymphadenopathy (but the largest is 0.5 cm diameter...), a biopsy of a cervical lymph node shows a complex picture. The lymph node capsule is preserved, the interfollicular T-zone is prominently expanded by a mixed infiltrate of histiocytes, small/intermediate/large T-lymphocytes with some prominent aggregates of large atypical T-cells. The B-zone is conserved but reduced. There are small foci of marked apoptosis, some associated with fibrin deposition and presence of "crescentic histiocytes", similar to the features of Kikuchi-Fujimoto disease.

By IHC the T-cell population is mixed, CD4(+) & CD8(+), with increased CD8-population. There is no loss of T-cell markers (CD2-CD3-CD5-CD7), the PCR for TCR rearrangement is negative (twice), no IGH rearrangement too.

There is no Follicular Dendritic cells expansion by CD21/CD23.

Unfortunately I can't upload pictures.

The question is: what is the likelyhood for a T-cell lymphoma without aberrant phenotype + no TCR rearrangement + mixed CD4/CD8 population?

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