Basically, you can compare two dependent ROC curves (obtained from the same data) by calculating a confidence interval for the difference between the individual ROC indices. A Wald test statistic then compares the observed difference divided by its standard error to the standard normal distribution to determine a p-value. There is some software out there that can calculate these statistics automatically, e.g.

• Medcalc: https://www.medcalc.org/manual/comparison-of-roc-curves.php
• Stata: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774909/#:~:text=To%20compare%20ROC%20curves%20we,to%20report%20a%20p%2Dvalue
• or R: https://rdrr.io/cran/pROC/man/roc.test.html

Hope this helps.

Best regards.

ROC curve analysis is a useful tool to determine the optimal cut-off value for independent variables in prediction models. The key steps are:

1. Construct the ROC curve by plotting the true positive rate (sensitivity) against the false positive rate (1-specificity) for different cut-off values of the predictor variable.

2. Calculate the area under the ROC curve (AUC) which summarizes the overall diagnostic ability of the predictor variable. An AUC of 1 represents perfect discrimination, while 0.5 indicates the predictor performs no better than chance.

3. Identify the cut-off value that optimizes the trade-off between sensitivity and specificity based on the clinical context. This can be done by:

- Selecting the point on the ROC curve closest to the top-left corner (0,1), which maximizes both sensitivity and specificity.

- Choosing a cut-off that achieves a desired sensitivity or specificity level based on the consequences of false positives and false negatives.

4. The optimal cut-off point corresponds to the predictor value that yields the desired balance of sensitivity/specificity or maximizes the Youden index (sensitivity + specificity - 1)

By analyzing the ROC curve, researchers can select the most clinically relevant cut-off for continuous or ordinal predictor variables in diagnostic or prognostic models, optimizing the trade-off between false positives and false negatives.

If you simply want to know if the AUROC of two models or datasets is statistically significant, use the DeLong test.

As an aside if this is combining independent variables to predict then calibration is as important as ROC curve analysis