My solute which is an antioxidant (0.25g) dissolves easily in acetone (25ml) (99.5%).
Whereas my solute (0.25g) does not dissolve in 25ml methanol (99.9%). However it only dissolves when 0.25g in 250ml methanol.
By the way it can't dissolve in water at all.
Have you checked the solubility curve of your solvent? It can tell you that is not soluble because has a very low solubility coefficient
I agree with Tomas. It is a very hydrophobic compound with no polar groups that allow it going into solution within polar solvents like water or methanol. Do you know something about its chemical structure?
Have you tried to do some mass spectroscopy to give you the peaks of some of the components? It might be that is not soluble in weak polar solvents but stronger ones and vice versa
hmm
finally i been told what the solute is. Its a powder containing xanthone and some wall material? so it seems to be a very hydrophobic fella.
I need to run antioxidant assay on it. Hmm im figuring if methanolic extract of it is a good idea (which seems to be most paper favourites). perhaps with acetone or erm other solvent that is more non polar.
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