External Ventricular Drainage Catheters coated with Rifampicin might affect platelet aggregation, what is the risk for local bleeding based on papers such as : Rifampicin-dependent antibodies target glycoprotein IIb/IIIa and cause clearance of human platelets in NOD/SCID mice. Br J Haematol. 2016 Jan;172(1):137-40. doi: 10.1111/bjh.13470. Epub 2015 Apr 29?
http://onlinelibrary.wiley.com/doi/10.1111/bjh.13470/abstract
Any drug that blocks these glycoprotein IIb/IIIa will decrease the platelet aggregation resulting in an increased bleeding potential of the patient as done by traditional anti platelet agents like clopidogril . Similarly if the receptor are damaged platelet aggregation will be reduced with increased bleeding tendencies. If you want to ask some thing else please give details
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