I am conducting experiments to repair the meniscus injury of rabbits by transplanting cells, and rabbits are also given daily injections of tacrolimus, an immunosuppressant.Now I want to test whether the transplanted cells have adverse effects on the liver and kidney functions of rabbits, but I don't know which liver and kidney items need to be tested.I hope friends who have had similar experience can give some suggestions.
I have seen a fair amount of research assess tissue and organ vitality using oxygen and microvasculature flow into those organs. Kidney in particular is a relatively easy organ to work with on this front.
Here is a publication on kidney and liver: Article Effect of Hyperoxia and Hypercapnia on Tissue Oxygen and Per...
Stem cells promote brain recovery after stroke: Article Human Umbilical Mesenchymal Stem Cells Promote Recovery Afte...
Few others of interest:Article Transplantation of Human Dental Pulp-Derived Stem Cells Prot...
https://pubmed.ncbi.nlm.nih.gov/30648908/
As an aside here is a system that can assess those parameters from a singular probe:
https://www.oxford-optronix.com/tissue-po2-blood-flow-monitoring
Thank you very much for your reply. Your answer is very meaningful to me！
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