Do I understand correctly that heterozygous Pmel mice have twice as less cells that carry anti-gp100 TCR? This should be right because of the allelic exclusion. If so, can one combine both homo and hetero mice in one experiment (if doesn't have enough homo) just by doubling the number of transferred hetero cells?
Paul Rutland
It is not necessarily the case that heterozygotes produce half as much of the mutated protein. Other factors will also influence production such as environment and other protective or deletarious background factors
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