I planned to develop nanoparticles of a drug. The drug is available both in Crystalline and Amorphous forms. The method of preparing the nanoparticles is by dissolving the drug and gelation of nanoparticles by ionic gellation method.
1. Whether I can use amorphous or crystalline form of drug for this?
2. If I want to use amorphous form whether Powder XRD is required to be performed on drug and nanoparticles or not? since amorphous form of drug will not show any sharp diffraction.
Thanks in advance
I do not know if I have understand the question correctly, but if you are going to dissolve your drug it does not matter if it is amorphous or crystalline. You usually talk about the solid state characteristics of the resulting nanosuspension that depend on manufacturing process; amorphous nanosuspension usually is the result of quenching method from an antisolvent, and crystalline nanosuspension resulting from wet bead milling (if you start with crystalline material).
yes it is required to do x-ray diffraction before and after formulation because amorphous form is less stable than crystal and have tendency to convert to satble form like crystalline form.
I think you should have better ration for selecting correct form of drugs either amorphous or crystalline.
Because of different physical properties (most important solubility ) first select best form of drugs.
Crystal are low soluble while amorphous are highly water soluble so depend upon objective you have to made selection for best type of drugs you want ( either want to increase solubility or want to achieve control form ).
However you can choose both form (but amorphous drug loading are relatively more because of distorted surface area wrt crystalline )
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