Hi Giulia

you can see the attached links

downloads.hindawi.com/journals/ap/2014/304757.pdf

downloads.hindawi.com/journals/ap/2014/304757.pdf 

www.particlesciences.com/services/drug-release-testing

Drug Release Testing / In-Vitro Release Testing (IVRTParticle Sciences provides a complete suite of drug release assays for a variety of dosage forms, drug release testing and In Vitro Release Testing (IVRT).

ptfarm.pl/pub/File/Acta_Poloniae/2010/3/217.pdf

ptfarm.pl/pub/File/Acta_Poloniae/2010/3/217.pdf 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527668/

Drug delivery and nanoparticles: Applications and hazardsThe use of nanotechnology in medicine and more specifically drug delivery is set to spread rapidly. Currently many substances are under investigation for drug delivery and more specifically for cancer therapy. Interestingly pharmaceutical sciences are ...

http://www.technicaljournalsonline....20II%20ISSUE%20I%20Article%2013.pdf

http://www.technicaljournalsonline.com/ijpsr/VOL%20II/IJPSR%20VOL%20II%20ISSUE%20I%20JANUARY%20MARCH%202011/IJPSR%20VOL%20II%20ISSUE%20I%20Article%2013.pdf 

http://dx.doi.org/10.1002/jps.20399/abstract

http://www.sciencedirect.com/science/article/pii/S0378517306004327

Preparation, characterization and in vitro drug release studies of novel polymeric nanoparticles

What is the simplest way to check drug release? - ResearchGate. Available from: https://www.researchgate.net/post/What_is_the_simplest_way_to_check_drug_release [accessed Feb 24, 2016].

The exact method will depend on the drug and nanoparticle formulation but there is a method that may be used for polymeric nanoparticles:

To measure drug release from nanoparticles, nanoparticles should be lyophilized, weighed, and resuspended in buffer (I used two different PBS/0.1% Tween-80 buffers, one at pH 7.4 and one at pH 6.5, but you can use whatever buffer is suitable for your drug/nanoparticle preparation) and then incubate in a 37 °C water bath. At various time points (I measured between 15 min and ten days) an aliquot of eluted drug medium should be removed for quantification; this volume must replaced with fresh buffer to prevent sink conditions. Drug release can be quantified by measuring the absorbance of the release media using a plate reader or HPLC, this value, of course, will be unique to the drug you are using. As a control you should also measure blank nanoparticles (with no drug) and make suitable standard curves for your drug concentration in buffer.

Please see the two attached papers of mine for methods and if you have any other questions please let me know.

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Article: Pharmacokinetics and biodistribution of lonidamine/paclitaxel loaded, EGFR-targeted nanoparticles in an orthotopic animal model of multi-drug resistant breast cancer

Lara Milane · Zhen-feng Duan · Mansoor Amiji

[Show abstract]

Full-text · Article · Aug 2011 · Nanomedicine: nanotechnology, biology, and medicine

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How do I measure a drug release profile for a drug encapsulated in a nanoparticle? - ResearchGate. Available from: https://www.researchgate.net/post/How_do_I_measure_a_drug_release_profile_for_a_drug_encapsulated_in_a_nanoparticle [accessed Feb 24, 2016].

Hi, Thanks for giving answer. Can you share your dissolution results, how you did its calculations so I can have a better idea.