If we have an host-guest complex, in water an equilibrium occurs. So you can have
ComplexGuest + H2O ComplexFree + GuestFree.
So I can calculate equilibrium constant, but in the most of papers they used NMR: at 5-6 different temperature you see different signals and with their ratio and different T ( plot linearly together) you can calculate Keq. (using Van't Hoff)
Do you know a method that doesn't use the VT NMR ? any kind of method also other types of techniques.
complex are around 2,000 g/mol and are just well soluble in water/DMF
Thanks
Theoretically, you can determine an equilibrium constant by NMR without temperature controller. The formation of complexes might result in line width broadening. The measurements at different temperatures allow determination the enthalpy and entropy formation of complexes.
Any technique which allows to quantify concentrations of ComplexFree and/or GuestFree is potentially applicable.
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