The most common MSCs are: bone marrow MSCs, adipose MSCs, placental MSCs, amniotic membrane MSCs, umbilical cord MSCs, and so on. Clinical studies have shown that these stem cells have therapeutic potential and promote the regeneration and repair of aging tissues.
Prolonged inflammatory conditions such as aging or alcoholic liver disease not only impact the liver but also affect the bone marrow. The use of autologous MSCs for regeneration in such diseases may not be efficacious, as suggested by findings in (PMID: 35295591)
Dhananjay Kumar"The use of autologous MSCs to promote regeneration in such diseases may not be effective."
This part of the statement is not necessarily accurate based on current research. Mesenchymal stem cells (MSCs) have shown promise in promoting tissue regeneration and modulating inflammation in various diseases, including liver diseases and bone marrow disorders. Autologous MSCs, derived from the patient's own tissues, are often considered safer due to lower risk of immune rejection.
Please refer to: doi.org/10.1016/j.ejcb.2019.04.002
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