It is appropriate to use a protein model made by homology modeling as a template for modeling of the protein mutant?

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For systematic review data extraction, should I use ITT or PP analysis, and count all randomized participants or only those who completed the study?

I am conducting a systematic review and meta analysis; as I am extracting data I realized there is a consort diagram that shows the number of patients from randomization till end of the study. So...

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How can I quantify MDEA (N-Methyldiethanolamine) with a GC-FID?

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15 July 2024 9,652 3 View

How can I quantify MDEA (N-Methyldiethanolamine) with a GC-FID?

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15 July 2024 2,181 10 View

How to download all 3D structures of IMPPAT database?

Hello I want to know is there any way to download all 3d structures of natural products of IMPPAT database?

14 June 2024 7,298 1 View

Why my PCR buffer is not working for one gene (while it was worked well for other gene)?

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13 June 2024 548 3 View

How to analyze multiple mind maps?

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Is there any replacement for primer blast (NCBI) to see if our primers are specifically designed for our desire PCR product?

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Microfluidic chip- how to prevent hydrogel peeling and retraction?

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Hi guys, Has anyone worked on fibroblasts?

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25 December 2023 4,969 0 View

How can I prepare virus for a TEM or SEM imaging?

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How to define an anisotropic material with asymmetric elastic compliance/stiffness matrix in ANSYS APDL?

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Why does my protein refolded to beta sheet during thermal denaturation analysis?

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Please explain how the plastic input value should be considered from the true stress-strain curve for the bilinear elastoplastic material model ?

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Is it necessary to covary exogenous constructs in a structural model?

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Jitesh Doshi

If sequence homology is good between your template PDB and protein of your interest, and model quality is also good, then you can use your model.. using template PDB will not be appropriate.

Danish Jasnaik

Hi,

If the homology between the modelled structure and the variant protein is good enough then you can go for it.