PPC is a rare type of cancer having extensive similarity with ovarian epithelial cancer. I am dealing with primary cell line of PPC and looking for well established one for comparison. Is it a good idea if I establish and characterize PPC primary cell line? Seeking advise from experienced person. Thank you in advance.
Many cancer researchers who do not well know the gynecology would make a misunderstanding that peritoneal carcinomas mean the disseminated tumor cells in the intraperitoneum from ovarian cancer. So, I strongly recommend you that in your research paper, you need to emphasize the "primary" and its pathological features.
Well, there is a PPC cell lines which have been established; PC880. The PC880 cell line was established from ascites fluid of a patient diagnosed with primary peritoneal carcinosarcoma. However, I could not find the information on ATCC Website, so that why not contact with the author of the following article?
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PC880 is the first cell line established from primary peritoneal carcinosarcoma, and the cytoskeletal composition indicated that these cells represent the sarcomatous elements of the tumor. PC880 cells, similar to ES-2 cells, adhered to type I collagen, and invaded a three-dimensional collagen matrix. The invasion of the interstitial matrix by both the peritoneal carcinosarcoma and the ovarian carcinoma cell line was mediated by cell surface proteoglycans, α2 integrin, and proteases. The invasive cell behavior of PC880 and ES-2 cells correlated with a high degree of motility, and with the lack of expression of the cell–cell adhesion molecule E-cadherin.
(Cited from Gynecol Oncol. 2003 Apr;89(1):60-72.)
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Thank you very much for the article. I will go through it. Hope to be in touch with you.
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