Hi everyone,
This may be a slightly (or extremely) stupid question, but: how many 5'-3' RNA ligase enzymes are there in the human genome? So far, the answer seems, surprisingly, to be one: RTCB.
While this seems extremely surprising to me, I've done a considerable amount of searching - both within the literature, by BLAST searches, by checking various GO term annotations and any other methods I can think of, and haven't come up with any others. While several "RNA ligase" ribozymes exist in the form of group 1/2 introns and the U6 snRNA, in terms of proteinaceous RNA ligase enzymes, RTCB is the only one I've found. Consistent with this idea, RTCB seems to be responsible for most of the reported RNA ligase activities thus far identified in the human cell (tRNA splicing, XBP1 mRNA intron removal . . . .).
Admittedly, this isn't a field I'm super-familiar with, so can anyone throw some light on this - for example, identify any blindingly obvious candidates I've missed, or any lesser-known candidates that may not be widely annotated in the literature?
Thanks in advance!
Dan
Check this:
http://link.springer.com/article/10.1007%2Fs00018-012-0944-2
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