Hello! I just came across with an article (Mullan et al., 2006 Arthritis and Rheumatism) where the reseaschers showed expression of VCAM-1 in synovial cells of joints in patients with rheumatoid arthritis. I thought that VCAM-1 is expressed exclusively in endothelial cells. Tried to search, but found only in Wikipedia about smooth muscle cells as a sourse for VCAM-1, but without referense. Please, if someone could help to provid the information with references whether there are other researchers showing the presence of VCAM-1 in other cells, that would be fantastic. Thank you in advance.
If you look at the 4th paragraph of the discussion of Carter et al., 2001, Immunology and Cell Biology, doi:10.1046/j.1440-1711.2001.01019.x, they state: "Vascular cell adhesion molecule-1 is also constitutively expressed on several other non-vascular cell types including type B SLC, bone marrow-derived stromal cells, thymic macrophages, thymic epithelial cells and follicular dendritic cells in tonsils." , with references to each. Hope this helps.
Thank you very much Alexandria! That's exactly what I was looking for.
This is an interesting stem cell point of possible proposal in that in embryo development or Galan points of development like per say brain development adhesion of cells turns out to be a good identifier like in DNA points of identification in association. Womb fluid, cerebral fluid and cerebellum comes to mind that could direct researchers to some pretty fancy petri dish Hebrews in jest.
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