Hi Mathieu,
As per my knowledge, cell adhesion and invasion are two antagonistic properties and hence unusual to be found together, especially in cancer cells.
It is the loss of the adhesion properties that actually allows the cells to invade or migrate, facilitating metastasis.
You can go through the following publications, if you are interested to know more about this topic.
http://www.ncbi.nlm.nih.gov/pubmed/11781114
http://www.ncbi.nlm.nih.gov/pubmed/8435473
Hello Mathieu,
Cell adhesion and invasion are not only antagonistic action, but both of these mechanisms can act in an interdependent manner as well, as loss of cell adhesion allows cell migration and invasion, followed by adhesion of the invading cell to the surrounding extracellular matrix, where cells can proliferate etc, for repair of tissue/ or may be part of pathogenesis.
So to answer you question, certain type of endothelial, progenitor and stem cells present in the human tissue have the ability to invade and differentiate with high adhesion potential. Endothelial, progenitor, and stem cells apply polarizing forces to the matrix that they adhere to, and the flexibility of extracellular matrix thus created is known to facilitate invasion.
Hope this helps clear your doubt,
Polly
Dear Polly,
Try probing Melanoma by microarray gene profiling, to study these behaviors simultaneously and their adhesion and invasion in a co-culture with human brain cells medium.
HI Abdul,
This question was asked by Mathieu and not me (polly).
And his question was whether invading cells had more adhesion potential, however thank u for the technical answer and I am sure you already know this but especially for mathieu I would like to further add that adhesion and invading potential would vary in co-culture ( ex-vivo) and in-vivo conditions (factors such as integrin binding, cell adhesion molecules are expressed differently in-vivo than ex-vivo).
Thank u,
Polly
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