H. pylori is a spiral-shaped bacterium commonly found in the stomach. The bacteria's shape and the way they move allow them to penetrate the stomach's protective mucous lining, where they produce substances that weaken the lining and make the stomach more susceptible to damage from gastric acids.
Actually, there is no consistent relationship between NCGS and H. pylori infection. These two conditions, indeed, are characterized by a different pathogenesis. However, it is important to consider that H. pylori may seldom induce duodenal lymphocytosis, a condition in which intraepithelial lymphocytes invade the mucosa. Since 50% of cases of NCGS are characterized by duodenal lymphocytosis, it is important to perform a differential diagnosis with H. pylori infection and other diseases associated to lymphocytosis such as inflammatory bowel disease, drug-induced damage or other autoimmune disorders. So, in conclusion, there is no link between NCGS and HP.
See Duodenal intraepithelial lymphocytosis with normal villous architecture in pediatric patients: Mayo Clinic experience, 2000-2009.
Shmidt E, Smyrk TC, Faubion WA, Oxentenko AS.
J Pediatr Gastroenterol Nutr. 2013
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