We normally see the elevation of serum or CSF neurofilament light (NfL) in people with Multiple Sclerosis (MS) and this elevation is correlated with MRI results such as demyelinating lesions in the CNS. Now, I would like to know is there any evidence out there that there is a normal level of serum/CSF NfL but MRI scanning is showing a lot of lesions in people with MS.
Thanks in advance,
The value of sNfL as a sensitive and clinically meaningful blood biomarker to monitor tissue damage and the effects of therapies in MS, so i think , if there is active lesions in MRI, the serum and CSF NFL will be abnormal. we need to study this important correlation on our patients with MS
Aqeel K. Hatem Yes you are right that if there are lesions NfL should be abnormal but I was wondering is there any exceptional study showing the opposite or similar. As there is some work showing elevation of NfL when there are no MRI lesions (or presymptomatic)Article Serum Neurofilament Light Chain Levels in Patients With Pres...
Thanks
Thank you for alerting us to the importance of clarifying this point, dear Drs. Hatem and Sen. Especially for the earliest stages of MS in which "black holes" have not yet become evident.
With black-hole lesions bordering CSF spaces, it was also interesting to learn whether electron microscopy not presented anybody with fragments of nerve fibers - comparable to the fragments of myelin sheaths that showed up in an MS-patient's CSF in 1978 (Herndon RM, Kasckow J. Electron microscopic studies of CSF sediment in demyelinating disease. Ann Neurol 1978 Dec;4(6):515-23.