17 Questions 36 Answers 0 Followers
Questions related from Monokesh Kumer Sen
We normally see the elevation of serum or CSF neurofilament light (NfL) in people with Multiple Sclerosis (MS) and this elevation is correlated with MRI results such as demyelinating lesions in...
28 April 2021 782 3 View
It is seen that during the behavioural test such as in open field walking beam tests mice/rat show a lot of exploration activities such as rearing, grooming, and head dipping. Is there any...
24 September 2019 4,235 0 View
I have a glial cell line called MO3.13. This is an immature cell line. I wan to differentiate into mature oligodendrocytes for my in vitro study? My question is how I can differentiate? What...
16 September 2019 8,505 1 View
Hi there, Pertussis toxin (PT) injection is commonly used to induce EAE. It is thought that PT injection breach the blood brain barrier (BBB) and facilitate T-cells migration into the CNS....
14 August 2019 6,945 3 View
For instance motor dysregulation may occur if there is a injury or inflammation in the motor pathways or similarly limbic system for cognition. My question is... which pathway in human or mouse...
13 February 2019 7,927 2 View
We know oligodendrocytes need increased number of ATP due to its function on myelin formation. Similarly neurons transmit the impulses. Both need energy and decrease supply of energy may cause...
22 January 2019 1,160 3 View
For some reasons most of the time multiple behavioral tests such as open field, rotarod, walking beam, and novel object recognition need to conduct in parallel. However, there may be time issue...
17 January 2019 1,360 3 View
Dears, To test anxiety and locomotion commonly "Open filed" and "Elevated-plus maze" apparatus are used. However, for certain reasons multiple instruments is not possible to use in same study. To...
05 January 2019 5,260 3 View
Can any one suggest the proper antibody to do immuno stain for CD8 cells in 4% PFA fixed mouse brain from anyones own experience that works? Thanks in advance Xx
24 August 2016 9,320 2 View
Hi, I am just wondering how I can collect CSF from mice as well as how much is possible from per mice? Thanks in advance, Monokesh
14 March 2016 9,446 4 View
Is there any possible biomarker has ever tasted from urine samples from MS patients?
22 February 2016 8,108 4 View
It is said nowadays that MS might be a neurodegenerative disease but the question is if it so then what are the differences between MS with other neurodegenerative diseases eg, Alzheimers disease...
14 February 2016 8,737 12 View
I want to fix acute brain slice after cutting and want to do immune and histology. My question how will I fix slices for these experiments? Can anyone here for giving advice? Thanks in advance
04 February 2016 10,012 6 View
It is commonly said that Multiple Sclerosis (MS) is an autoimmune disease but recent researches have showed some opposite results where immune reaction happens after degeneration. Unfortunately...
04 February 2016 8,495 17 View
Hi, I want to separate plasma from mice blood and store plasma sample for long time. In which process the viability/validity of my sample will be same as fresh sample? Thanks
07 November 2015 3,182 2 View
Hi, I need to separate oligodendrocyte progenitor cell from mature oligodendrocytes in vitro. IS there anyone knows how to do it? Thanks in advance......
27 October 2015 286 7 View
Neurotoxin, Cuprizone, is used for demyelination in mouse brain for de and remyelination. My inquiry is how it demyelinates?
05 September 2015 1,191 4 View
