I would like to know about cancer cell differentiation. After inducing differentiation it may reduce tumorigenicity. If somebody can provide reference article and reference drug, that would be very helpful for my research. Thanks in Advance.
The treatment with all trans retinoic acid (ATRA) induces the differentiation of squamous cancer cells as well as APL, also well known as the subtype of AML. Further, vitamin A is famous for the differentiation effect of neuroblastoma cells.
if this is of relevance for your research, you might want to have a look at a paper published in Cell in 2009, reporting interesting findings about salinomycin, exerting antitumor activity possibly through inducation of differentiation in the setting of breast cancer stem cells.
Gupta, P.B., Onder, T.T., Jiang, G., Tao, K., Kuperwasser, C., Weinberg, R.A., and Lander, E.S. (2009). Cell Identification of selective inhibitors of cancer stem cells by high-throughput screening.
Thank for your suggestion Go J Yoshida and Dimitrios Zardavas.
I will go through those references.
And I will ask you some more suggestion.
With human promyelocytic leukemia cells (HL-60 ) spontaneous differentiation to mature granulocytes can be induced by compounds such as dimethyl sulfoxide (DMSO), or retinoic acid.
Thank you Minu Dietlinde Tizabi.
Your reference was very informative one. I am really appreciate you for giving such useful references.
and thanks to Ralf Axel Hilger for your suggestion.
If somebody can give more specifically for colon cancer cell line differentiation (HCT116 and HT-29).
Please see the following publication and related references:
Also several leukemias can be induced to terminally differentiate using GM-CSF.
Cancer Lett. 1982 Sep;16(3):287-95.
Regression and differentiation of neuroblastoma tumors in mice treated with differentiating agents--prostaglandin E1 and a phosphodiesterase inhibitor, RO 20-1724.
Anderson DW, Crowle AJ.
Abstract
Prostaglandin E1 (PGE) and d, 1-4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone (RO 20-1724, an experimental cyclic nucleotide phosphodiesterase inhibitor) cause cell death and cyclic AMP-mediated differentiation of murine neuroblastoma (NB) (cell line C-1300) cells in vitro. We report, for the first time, that these agents can be used in vivo to cause regression of NBs in A/Jax mice. These drugs were also able to slow the growth of primary tumors, prevent metastases, and cause morphological differentiation of tumors. The similarity of the response of human and mouse NB cells to differentiating drugs indicate that these agents have the potential to replace or support conventional chemotherapy in treatment individualized to NB. The mouse model of NB provides an excellent means to study the effectiveness of alternative drug therapy in vivo.
PMID:
6891284
[PubMed - indexed for MEDLINE]
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